The Columbia University Department of Systems Biology brings together researchers specializing in computational biology, experimental biology, and technology development to discover how biological traits emerge from complex molecular networks.
Systems biology and computational biology are becoming increasingly important disciplines in the biological sciences. Through PhD graduate education and postdoctoral training we prepare young scientists to become leaders in this exciting and rapidly growing field.
ProfileSystems Biology and Women's Health: A Q+A with Tal Korem, PhD
As a member of the Program for Mathematical Genomics, Tal Korem is bringing his interests in systems biology, quantitative research, and the human microbiome to areas of clinical relevance. For Dr. Korem, that clinical focus is women’s reproductive health. “There is still a lot we don’t understand that relates to women’s health, to fertility, and to birth outcomes, and how microbes play a role in all of this,” says Dr. Korem. In this Q+A, learn about Dr. Korem's ongoing research and his path to the field of systems biology and women's health.
Research NewsDSB Retreat Boasts Diverse Research, Spotlights Young Investigators
Each year the Department of Systems Biology community comes together for an off-campus retreat to discuss science, share ongoing research and to network. During this year's two-day program, held in Ellenville, NY, research presentations were primarily delivered by young investigators, shining a light on the ongoing work by our graduate students and post-docs.
Research NewsNew Method Detects Genetic Expression Disruptors, Improves Diagnosis of Rare Disease
In a new study published in Science, researchers from New York Genome Center and Columbia University demonstrate a new method for analyzing genomes to better identify all mutations that disrupt gene function. The study was led by Pejman Mohammadi, PhD, a former postdoctoral scientist at the New York Genome Center and Columbia, and supervised by Tuuli Lappalainen, PhD, core faculty member at the New York Genome Center and an assistant professor of systems biology.
Research NewsPersonalized Gene Delivery to the Gut
A team of researchers, led by Dr. Harris Wang, has engineered bacteria to benefit and improve the overall health of our gut microbiome. In a proof-of-concept paper published in Nature Methods, the researchers demonstrate MAGIC, a gene delivery system that ‘hacks’ the gut microbiome to perform any desired genetic function, from harvesting energy from food and protecting against pathogen invasion to bolstering anti-inflammatory properties and regulating immune responses.
Research NewsBiological ‘Rosetta Stone’ Brings Scientists Closer to Deciphering How the Body is Built
An international research team co-led by Richard Mann, PhD, from the Department of Systems Biology, have discovered a method that can systematically identify the role each Hox gene plays in a developing fruit fly. Their results, reported recently in Nature Communications, offer a new path forward for researchers hoping to make sense of a process that is equal parts chaotic and precise, and that is critical to understanding not only growth and development but also aging and disease.
Events and Seminars
November 19, 2019 - 5:00pm
Nicholas Tatonetti, PhD
November 26, 2019 - 5:00pm
Molly Przeworski, PhD