Sagi Shapira

Sagi Shapira


Assistant Professor, Department of Systems Biology


Department of Systems Biology
Department of Microbiology and Immunology


(212) 305-2865

Sagi Shapira was recruited to Columbia in 2011 as an assistant professor in the Columbia Initiative in Systems Biology and the Department of Microbiology and Immunology. His laboratory is working to decipher the genetic and molecular circuitry at the interface of host–pathogen interactions. His laboratory studies how this circuitry controls cellular responses to infection, imparts selective pressure on viruses, and affects disease progression. Using animal models of infectious disease, molecular biology, and genomic and computational methods, he seeks to generate mechanistic models of the dynamic interactions between host and pathogen. The efforts are aimed at developing general strategies for the study of host–pathogen dynamics. A mechanistic understanding of these relationships provides important insights into cellular machinery that control basic cell biology and has broad implications in human translational immunology and infectious disease research.

More News


Ancient Part of Immune System May Underpin Severe COVID
One of the immune system’s oldest branches, called complement, may be influencing the severity of COVID disease, according to a new study in Nature Medicine led by Drs. Sagi Shapira and Nicholas Tatonetti of the Department of Systems Biology.
New COVID-19 Pilot Grants Awarded to Systems Biology Faculty
Drs. Sagi Shapira and Nicholas Tatonetti, faculty in the Department of Systems Biology, have been awarded a new pilot grant for research geared toward understanding the novel SARS-CoV-2 virus.
Detailed Map Gives Scientists a New Window into how Human-Infecting Viruses Work
Columbia University biologists leveraged a computational method to map protein-protein interactions between all known human-infecting viruses and the cells they infect. The method, along with the data that it generated, has spawned a wealth of information toward improving our understanding of how viruses manipulate the cells that they infect and cause disease. Among its findings, the work uncovered a role for estrogen receptor in regulating Zika Virus infection, as well as links between cancer and the human papillomavirus. The research, led by Dr. Sagi Shapira, appears Aug. 29 in the journal, Cell.
Sex May Not Have Evolved Without Changes in Immune System
Sexual reproduction may have never become possible if organisms hadn’t evolved a way to restrain the immune system during fertilization, according to a new study from the lab of Sagi Shapira, PhD, assistant Professor of Systems Biology.
Department of Systems Biology Opens New Biotechnology Development Hub
The new space will promote the design of new experimental methods for studying biological systems, and enable an expansion of the Columbia Genome Center's next-generation sequencing capabilities.