An analysis of all gene mutations in nearly 140 brain tumors has uncovered most of the genes responsible for driving glioblastoma. The analysis found 18 new driver genes (labeled red), never before implicated in glioblastoma and correctly identified the 15 previously known driver genes (labeled blue). The graphs show mutated genes that are commonly found in varying numbers in glioblastoma (left), that frequently contain insertions (middle), and that frequently contain deletions (right). Genes represented by blue dots in the graphs were statistically most likely to be driver genes.
A team of Columbia University Medical Center researchers has identified 18 new genes responsible for driving glioblastoma multiforme, the most common—and most aggressive—form of brain cancer in adults. The study was published August 5, 2013, in the journal Nature Genetics.
The Columbia team used a combination of high-throughput DNA sequencing and a new method of statistical analysis developed by co-author Raul Rabadan, an assistant professor in the Department of Systems Biology, to generate a short list of candidate gene mutations that were highly likely to drive cancer, as opposed to mutations that have no effect.
Considering these results along with a previous study this group conducted, Rabadan and collaborators Antonio Iavarone and Anna Lasorella point out that approximately 15% of glioblastomas could now be targeted with drugs that have already been approved by the FDA. As Lasorella remarks in an article for the CUMC Newsroom, “There is no reason why these patients couldn’t receive these drugs now in clinical trials.”