Zachary Carpenter completed his PhD as a Pharmacology and Molecular Signaling student and fellow of the Med into Grad Scholars Program at Columbia University's College of Physicians and Surgeons. His participation in the MIG Scholars program at Columbia enabled him to obtain medical experience in pediatric and adult hematological oncology, which was his main research focus under Dr. Rabadan and Dr. Adolfo Ferrando. As a graduate student his interests included structure-based drug design, in silico pharmacology, and clonal evolution and phasing in cancer.
Previously, Zach graduated from the College of New Jersey in 2009 with a BS in biology and minors in chemistry and computer science. Zach has a strong interest at the intersection between translational medicine and high throughput next-generation techniques and algorithms. During his undergraduate studies Zach was involved in several bioinformatics research projects, including an REU at UMass Amherst—focused on the ubiquitin proteasome system—and a brief study at Oxford University.
Palomero T, Couronné L, Khiabanian H, Kim MY, Ambesi-Impiombato A, Perez-Garcia A, Carpenter Z, Abate F, Allegretta M, Haydu JE, Jiang X, Lossos IS, Nicolas C, Balbin M, Bastard C, Bhagat G, Piris MA, Campo E, Bernard OA, Rabadan R, Ferrando AA. Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in perippheral T cell lumphomas. Nat Genet. 2014 Feb;46(2):166-70.
Oyer JA, Huang X, Zheng Y, Shim J, Ezponda T, Carpenter Z, Allegretta M, Okot-Kotber CI, Patel JP, Melnick A, Levine RL, Ferrando A, Mackerell AD Jr, Kelleher NL, Licht JD, Popovic R. Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies. Leukemia. 2014 Jan;28(1):198-201.
Tzoneva G, Perez-Garcia A, Carpenter Z, Khiabanian H, Tosello V, Allegretta M, Paietta E, Racevskis J, Rowe JM, Tallman MS, Paganin M, Basso G, Hof J, Kirschner-Schwabe R, Palomero T, Rabadan R, Ferrando A. Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Nat Med. 2013 Mar;19(3):368-71.
Anthony SJ, St Leger JA, Pugliares K, Ip HS, Chan JM, Carpenter ZW, Navarrete-Macias I, Sanchez-Leon M, Saliki JT, Pedersen J, Karesh W, Daszak P, Rabadan R, Rowles T, Lipkin WI. Emergence of fatal avian influenza in New england harbor seals. MBio. 2012 Jul 31;3(4):e00166-12.
Della Gatta G, Palomero T, Perez-Garcia A, Ambesi-Impiombato A, Bansal M, Carpenter ZW, De Keersmaecker K, Sole X, Xu L, Paietta E, Racevskis J, Wiernik PH, Rowe JM, Meijerink JP, Califano A, Ferrando AA. Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL. Nat Med. 2012 Feb 26;18(3):436-40.
Carpenter ZW, Hernandez C, Chan J, Rabaran R. 2011. The origin and evolution of a pandemic virus. MAGNet Newsletter, 2011.
Zhou Y, Carpenter ZW, Brennan G, Nambu JR. The unique Morgue ubiquitination protein is conserved in a diverse but restricted set of invertebrates. Mol Biol Evol. 2009 Oct;26(10):2245-59.